منابع مشابه
Zinc Finger Protein Gene Complexes
Two murine homologs of the Drosophila Kriippel gene, a member of the gap class of developmental control genes that encode a protein with zinc fingers, were mapped to mouse chromosomes 8 and 11 by using somatic cell hybrids and an interspecific backcross. Surprisingly, both genes were closely linked to two previously mapped, Krtippelrelated zinc finger protein genes, suggesting that they are par...
متن کاملSimilarity Trees for Zinc Finger Protein Design
Zinc finger domains are protein structures first identified in the Xenopus transcription factor TFIIIA. A zinc finger is composed of 20 to 30 amino-acid residues. There are two residues at both extremities of the domain which are involved in the tetrahedral coordination of a zinc atom. It has been proposed that such a domain interacts with the DNA. Many classes of zinc fingers are characterized...
متن کاملZinc-Finger Antiviral Protein Inhibits XMRV Infection
BACKGROUND The zinc-finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses, including Moloney murine leukemia virus (MoMLV), HIV-1, and certain alphaviruses and filoviruses. ZAP binds to specific viral mRNAs and recruits cellular mRNA degradation machinery to degrade the target RNA. The common features of ZAP-responsive RNA sequences remain...
متن کاملMyocardial ischemic preconditioning upregulated protein 1(Mipu1):zinc finger protein 667 - a multifunctional KRAB/C2H2 zinc finger protein
Myocardial ischemic preconditioning upregulated protein 1 (Mipu1) is a newly discovered upregulated gene produced in rats during the myocardial ischemic preconditioning process. Mipu1 cDNA contains a 1824-base pair open reading frame and encodes a 608 amino acid protein with an N-terminal Krüppel-associated box (KRAB) domain and classical zinc finger C2H2 motifs in the C-terminus. Mipu1 protein...
متن کاملZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool
ZiFiT (Zinc Finger Targeter) is a simple and intuitive web-based tool that provides an interface to identify potential binding sites for engineered zinc finger proteins (ZFPs) in user-supplied DNA sequences. In this updated version, ZiFiT identifies potential sites for ZFPs made by both the modular assembly and OPEN engineering methods. In addition, ZiFiT now integrates additional tools and res...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/37413